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Copernicus Therapeutics, Inc. is a privately-held company developing products
for human gene therapy and vaccination. Copernicus was established in 1997 based on technologies
discovered at Case Western Reserve University that provide the foundation for the use of DNA as
drugs.
Copernicus is not involved in gene discovery or the linkage of genetic defects to
disease. Copernicus' business focuses on using its technologies to make and sell gene therapy
products to treat, cure or prevent human diseases - products that work.
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 Copernicus Therapeutics, Inc. presented data at the American Society of Gene
Therapy meeting showing that their compacted DNA formulation can effectively
transfect non-dividing human cells, solving the problem of restricted access
of plasmid DNA to the nucleus.
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 Copernicus has developed three technology platforms that provide unique
opportunities to develop novel therapeutics. These platforms have separate
therapeutic applications but, when combined, can result in synergistic
advantages.
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 Copernicus' technologies present opportunities for products in many important
markets. The Company's delivery technologies solve many of the problems that
have hindered gene therapy, with a market projected to be worth $12 billion
by 2007.
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 Copernicus has exclusive, world-wide licenses to twelve U.S. patents issued to Case Western Reserve University, three U.S. patents issued to Copernicus and four pending U.S. patent applications that provide strong support for the commercialization of its technologies. Over 30 non-US patents extend protection throughout world markets.
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